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Archiving of clinical materials as Formalin-Fixed, Paraffin-Embedded (FFPE) samples is a common practice. However, the methods used for fixation and storage significantly damage the nucleic acids from these samples. Additionally, FFPE DNA samples are often available in only very small amounts. As a result, it can be challenging to construct libraries of sufficient quality and quantity to obtain good sequence data.

The NEBNext product line addresses these issues in two ways:
  • The NEBNext FFPE DNA Repair v2 Module (E7360S/L) is an optimized cocktail of enzymes designed to repair FFPE DNA, and supplied with optimized reagents to enable a streamlined workflow for NGS library preparation.  
  • NEBNext Ultra™ II  (E7645S/L) can be used to produce high quality libraries from low nanogram amounts of FFPE DNA samples, and is recommended for library prep when input DNA quantity and quality is limited.
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Protocols for FFPE DNA
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Products and content are covered by one or more patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc (NEB). The use of trademark symbols does not necessarily indicate that the name is trademarked in the country where it is being read; it indicates where the content was originally developed. The use of this product may require the buyer to obtain additional third-party intellectual property rights for certain applications. For more information, please email

This product is intended for research purposes only. This product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.