Histone H3.2 Human, Recombinant
Histone H3.2 is an H3 variant that is found in all eukaryotes, except budding yeast. It is replication-dependent and is associated with gene silencing.
- Highly pure, recombinant protein
- Identity confirmed using Edman Degradation to sequence intact protein; mass confirmed by ESI-TOF MS
- Tested for exonuclease, endonuclease and protease contamination
Histone H3 combines with Histone H4 to form the H3/H4 tetramer. Two H2A/H2B heterodimers interact with an H3/H4 tetramer to form the histone octamer. It is also modified by various enzymes and can act as a substrate for them. These modifications have been shown to be important in gene regulation.
Protein Sequence: ARTKQ TARKS TGGKA PRKQL ATKAA RKSAP ATGGV KKPHR YRPGT VALRE IRRYQ KSTEL LIRKL PFQRL VREIA QDFKT DLRFQ SSAVM ALQEA SEAYL VGLFE DTNLC AIHAK RVTIM PKDIQ LARRI RGERA (Genbank accession number: Q71DI3)
Product SourceAn E.coli strain that carries a plasmid encoding the cloned human histone H3.2 gene, HIST2H3A or HIST2H3C. (Genbank accession number: BC130637)
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