Histone H2A combines with Histone H2B to form the H2A-H2B heterodimer. Two H2A/H2B heterodimers interact with an H3/H4 tetramer to form the histone octamer. (1,2) Histone H2A is also modified by various enzymes and can act as a substrate for them. These modifications have been shown to be important in gene regulation.
Protein Sequence: SGRGK QGGKA RAKAK SRSSR AGLQF PVGRV HRLLR KGNYS ERVGA GAPVY LAAVL EYLTA EILEL AGNAA RDNKK TRIIP RHLQL AIRND EELNK LLGRV TIAQG GVLPN IQAVL LPKKT ESHHK AKGK (Genbank accession number: AAN59960)
Product SourceAn E. coli strain that carries a plasmid encoding the cloned human Histone H2A gene, HIST3H2A. (Genbank accession number: AY131974)
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