Human DNA (cytosine-5) Methyltransferase (Dnmt3B) Carboxy-terminal Ab
- Catalog # M0232 was discontinued on January 01, 2013 ;
Dnmt3B is a de novo mammalian methyltransferase that is architecturally similar to Dnmt1 and Dnmt3A (1). The carboxy terminus (C- terminus) of human Dnmt3B contains the conserved catalytic motifs. This region is responsible for catalytic function. Dnmt3B cooperates with other DNA methyltransferases to maintain DNA methylation (2,3). Dnmt3B null embryos show multiple developmental defects including growth impairment and neural tube formation (4). Catalytic domain mutation in human Dnmt3B gene is associated with ICF syndrome (5). The predicted molecular weight of Dnmt3B is 97.5 kDa.
Human DNA (cytosine-5) Methyltransferase (Dnmt3B) Carboxy-terminal Antibody detects less than 20 ng of Dnmt3B in the cell extract using anti-rabbit Phototope-HRP Western Detection Kit (available from Cell Signaling Technology).
- Western blotting
- Product Categories:
- Discontinued Products
- Citations & Technical Literature
- Quality, Safety & Legal
Ineligible item added to cart
Based on your Freezer Program type, you are trying to add a product to your cart that is either not allowed or not allowed with the existing contents of your cart. Please review and update your order accordingly If you have any questions, please contact Customer Service at [email protected] or 1-800-632-5227 x 8.