Human DNA (cytosine-5) Methyltransferase (Dnmt1) Amino-terminal Ab
- Catalog # M0231 was discontinued on January 05, 2015 ;
Amino terminal (N-terminal) of human Dnmt1 has been shown to bind proliferating cell nuclear antigen (PCNA) and histone deactylase (1,2). Deletion of this region stimulates DNA methylation (3). In neoplastic transformed cells methylation pattern is abnormal, leading to the speculation that Dnmt1 may be involved in such processes (4).
Human DNA (cytosine-5) Methyltransferase (Dnmt1) Amino-terminal Antibody detects less than 10 ng of Dnmt1 in the cell extract using anti-rabbit Phototope-HRP Western Detection Kit (available from Cell Signaling Technology).
Dnmt1 Amino-terminal Antibody:
Polyclonal antibodies are produced by immunizing rabbit with a KLH coupled synthetic peptide corresponding to residues in the N-terminal region of human Dnmt1. The antibodies are purified in a protein A column.Storage Conditions:
10 mM HEPES
150 mM NaCl
100 µg/ml BSA
pH 7.5 @ 25°C
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