Human DNA (cytosine-5) Methyltransferase (Dnmt1)
Dnmt1 methylates cytosine residues in hemimethylated DNA in the sequence of 5'...CG...3' (1,2). Mammalian Dnmt1 is believed to be involved in carcinogenesis, embryonic development and several other biological functions (3-5).
The bulk of the methylation takes place during DNA replication in the S-phase of the cell cycle (6).
Product SourceDnmt1 is expressed from human Dnmt1 cDNA using a baculovirus expression system (1,7).
The following reagents are supplied with this product:
Store at (°C) Concentration Dnmt1 Reaction Buffer -20 10X Purified BSA -20 10 mg/ml S-adenosylmethionine (SAM) -20 32 mM
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