Human DNA (cytosine-5) Methyltransferase (Dnmt3A) Amino-terminal Ab
- Catalog # M0229 was discontinued on January 01, 2013 ;
Dnmt3A is a de novo mammalian methyltransferase that is architecturally similar to Dnmt1 and Dnmt3B (1). The amino terminus (N-terminus) of human Dnmt3A contains various motifs that recruit transcriptional repressors (2). Dnmt3A cooperates with other DNA methyltransferases to maintain DNA methylation (3). Dnmt3A null embryos show multiple developmental defects including growth impairment and neural tube formation (4). Overexpression of DNA methyltransferases are observed in acute and chronic myelogenous leukemia cells (5). The apparent molecular weight for Dnmt3A is 101.5 kDa.
Human DNA (cytosine-5) Methyltransferase (Dnmt3A) amino-terminal antibody detects less than 20 ng of Dnmt3A in the cell extract using anti-rabbit Phototope-HRP Western Detection Kit (available from Cell Signaling Technology).Storage Conditions:
10 mM Sodium HEPES
150 mM NaCl
100 µg/ml BSA
pH 7.5 @ 25°C
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