Programmable Nucleases

Site-specific gene modification and highly specific in vitro cutting is enabled by nucleases that can be easily programmed with nucleic acids. NEB’s portfolio of Cas enzymes support RNA-guided programmable cutting, binding, and nicking of DNA. In addition to RNA-guided Cas enzymes, Tth Argonaute (TtAgo) (NEB #M0665) can be programmed with DNA, further expanding the range of available tools.

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Programmable Nucleases

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Programmable Nucleases

    Publications related to

    Programmable Nucleases

  1. Morgan, R.D., Luyten, Y.A., Johnson, S.A., Clough, E.M., Clark, T.A. and Roberts, R.J. 2016. Novel m4C modification in type I restriction-modification systems. Nucleic Acids Res. . Nov, PubMedID: 27580720, DOI:
  2. Roberts, R.J., Vincze, T., Posfai, J., Macelis, D. 2014. REBASE - A database for DNA restriction and modification: enzymes, genes and genomes Nucleic Acids Research, Advance Access . , PubMedID: , DOI:
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