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DNA Modifying Enzymes & Cloning Technologies

Advances in molecular biology require constant innovation and forward progress in the tools and techniques at the core of the field. New England Biolabs is committed to providing a wide variety of essential reagents that serve to advance the frontier of DNA-based manipulations.

NEB’s enzymology expertise sets it apart from competitors, allowing us to produce enzymes for molecular biology that deliver; our highly pure enzymes, over 250 of which are recombinant, offer exceptional performance and value.

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DNA Modifying Enzymes & Cloning Technologies includes these subcategories:
DNA Ligase Products
DNA Repair Enzymes and Structure-specific Endonucleases
Exonucleases and Non-specific Endonucleases
Phosphatases & Sulfurylases
ssDNA Binding Proteins
DNA Labeling
Other Products
Protocols for DNA Modifying Enzymes & Cloning Technologies
Application Notes for DNA Modifying Enzymes & Cloning Technologies
    Publications related to DNA Modifying Enzymes & Cloning Technologies
  1. Morgan, R.D., Luyten, Y.A., Johnson, S.A., Clough, E.M., Clark, T.A. and Roberts, R.J. 2016. Novel m4C modification in type I restriction-modification systems. Nucleic Acids Res. . Nov, PubMedID: 27580720, DOI:
  2. Ee, R., Lim, Y.L., Yin, W.F., See-Too, W.S., Roberts, R.J. and Chan, K.G. 2016. Novel Methyltransferase Recognition Motif Identified in Chania multitudinisentens RB-25(T) gen. nov., sp. nov. Front Microbiol . 206, PubMedID: 27630623 , DOI:
  3. Martinez, F.L., Anton, B.P., DasSharma, P., ​Pajal, V., Irazusta, V., Roberts, R.J., DasSharma, S. 2019. Complete genome sequence and methylome analysis of micrococcus luteus SA211, a halophilic, lithium-tolerant Actinobacterium from Argentina Microbiol Resour Announc. 8 (4), PubMedID: 30701250, DOI: 10.1128/MRA.01557-18
  4. Mauris, J.and Evans, T.C., Jr. 2010. A human PMS2 homologue from Aquifex aeolicus stimulates an ATP-dependent DNA helicase. J Biol.Chem. 285(15), PubMedID: 20129926, DOI:
  5. Fomenkov, A., Vincze, T., Mersha, F., Roberts, R.J. 2018. Complete genome sequence and methylome analysis of Bacillus caldolyticus NEB414. Genome Announcements. 6 (6), PubMedID: 29439055 , DOI: 10.1128/genomeA.01605-17
  6. Pirone-Davies, C., Hoffmann, M., Roberts, R.J., Muruvanda, T., Timme, R.E., Strain, E., Luo, Y., Payne, J., Luong, K., Song, Y., Tsai, Y.C., Boitano, M., Clark, T.A., Korlach, J., Evans, P.S., Allard, M.W. 2015. Genome-Wide Methylation Patterns in Salmonella enterica Subsp. enterica Serovars PLoS One. 10(4), PubMedID: 25860355, DOI:
  7. Seib, K.L., Jen, F.E., Tan, A., Scott, A.L., Kumar, R., Power, P.M., Chen, L.T., Wu, H.J., Wang, A.H., Hill, D.M., Luyten, Y.A., Morgan, R.D., Roberts, R.J., Maiden, M.C., Boitano, M., Clark, T.A., Korlach, J., Rao, D.N. and Jennings, M.P. 2015. Specificity of the ModAll, ModA12 and ModD1 epigenetic regulator N6-adenine DNA methyltransferases of Neisseria Meningitidis Nucleic Acids Res. 43(8), PubMedID: 25845594, DOI:
  8. Fomenkov, A., Lunnen, K.D., Zhu, Z., Anton, B.P., Wilson, G.G., Vincze, T. and Roberts, R.J. 2015. Complete genome sequence and methylome analysis of bacillus strain x1 Genome Announc. 3(1), PubMedID: 25700417, DOI:
  9. Anton, B.P., Mongodin, E.F., Agrawal, S., Fomenkov, A., Byrd, D.R., Roberts, R.J. and Raleigh, E.A. 2015. Complete Genome Sequence of ER2796, a DNA Methyltransferase-Deficient Strain of Escherichia coli K-12 PLoS One. 10(5), PubMedID: 26010885, DOI:
  10. Roberts, R.J., Vincze, T., Posfai, J., Macelis, D. 2014. REBASE - A database for DNA restriction and modification: enzymes, genes and genomes Nucleic Acids Research, Advance Access . , PubMedID: , DOI:
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