FAQ: Will EcoGII Methyltransferase methylate DNA/RNA hybrids?

Although adenine residues present in the RNA strand can and may be modified, EcoGII Methyltransferase will preferentially modify the adenine residues present in the DNA strand of a DNA/RNA hybrid molecule.

Please see the table on the product description page for more details on methylation levels of various substrates by EcoGII Methyltransferase.