Heparin and heparan sulfate (HS) glycosaminoglycans are linear sulfated polysaccharides located on cell-surface membranes and in extracellular matrices in virtually all animal tissues.
- Heparin and HS have been implicated in cell biological processes, cell adhesion and regulation of enzymatic catalysis (1).
- HS chains have been shown to interact with a variety of growth factors, chemokines, extracellular matrix proteins, and enzymes, including antithrombin, fibroblast growth factors, and vascular endothelial growth factor (2).
- Heparin has been widely used as an anticoagulant drug (3,4), and it has been shown to regulate cellular process by binding, stabilizing and activating various growth factors (5).
- Fritz, T., et al (1994) J Biol Chem 269(46), 28809-28814. PMID: 7961837
- Linhardt, R. J., et al. (1990) Biochemistry 29(10), 2611-2617. PMID: 2334685
- Linhardt, R. J. and Gunay, N. S. (1999) Semin. Thromb. Hemost. 25 Suppl. 3, 5-16. PMID: 10549711
- Casu, B., et al. (2002) Biochemistry 41(33), 10519-10528. PMID: 12173939
- Knudsen, C. B., Knudsen, W. (2001) Semin. Cell. Dev. Biol. 12, 69-78. PMID: 11292372
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